Design of an immunization strategy based on recombinant proteins of the measles virus in the context of a changing epidemiology

Immigrants: Potential Menace for Measles Elimination Target in Iran

     Measles is a highly contagious disease. By the end of 2013, 84% of children had received at least a single dose of measles vaccine by their second birthday, and 148 countries had included a second dose as part of routine immunization. In 2002, the Iranian Ministry of Health and Medical Education developed a comprehensive strategy to eliminate Measles including mass immunization campaign fo...

Construction of a Minigenome Rescue System for Measles Virus, AIK-c Strain

Background:In the recent decade, the reverse genetics method has been broadly used for rescue of negative-stranded RNA viruses from cDNA or viral minigenomes. This technique has been applied to study different steps in virus replication and virus-host interactions. Reverse genetics could also be implemented for design of new vaccines. The T7 RNA polymerase activity as well as virus (nucleocapsi...

Excessive Attenuation of Measles Virus as a Possible Cause of Failure in Measles Immunization

Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice

Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immuno-dominant epitopes have been shown to induce immune responses. Furthermore, for safety of immunization, access to efficient adjuvants against FMD virus seems to be critical.Materi...

CpG Motif as an Adjuvant in Immunization of a Recombinant Plasmid Encoding Hepatitis C Virus Core Protein